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Weight loss resistance is largely due to inflammation inflicting damage at the cellular level, and to cell membranes in particular. Sadly, this is an area that has been ignored in health care, including integrative and functional medicine. In my Radical Metabolism plan, I explain that there are three metabolically active tissues that directly relate to how your body uses energy and stores fat. Each of these three tissues requires a different type of fuel and has specific nutritional requirements for optimal function. Unless each is specifically addressed in your diet, your slim-down may end up in a shutdown. The good news is that the Radical foods that reduce inflammation and fuel your cells also help you achieve a healthy weight. A Healthy Body Has a Healthy Weight The side effects of unhealthy weight gain start out the same for all of us – fatigue, joint pain, sleep problems, and diseases like type 2 diabetes – but autoimmune disease can exacerbate all of these, bringing them on more rapidly or with more intensity.